The antibacterial and angiogenic effect of magnesium oxide in a | ResearchBunny

Index

Abstract

This study investigates a hydroxyapatite and magnesium oxide (HAp/MgO) bone substitute to combat bone graft infections and promote regeneration. Different sintering temperatures yielded granules with varying properties, influencing antibacterial activity and cytocompatibility. Granules sintered at 1100 °C showed optimal balance, reducing bacterial proliferation while supporting osteoblast growth. In vivo testing demonstrated angiogenesis stimulation without inflammation. MgO's dual effect makes this a promising antibacterial bone substitute.

Publisher

Scientific Reports

Published On

Nov 05, 2020

Authors

Catarina C. Coelho, Tatiana Padrão, Laura Costa, Marta T. Pinto, Paulo C. Costa, Valentina F. Domingues, Paulo A. Quadros, Fernando J. Monteiro, Susana R. Sousa

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