This study investigates a hydroxyapatite and magnesium oxide (HAp/MgO) bone substitute to combat bone graft infections and promote regeneration. Different sintering temperatures yielded granules with varying properties, influencing antibacterial activity and cytocompatibility. Granules sintered at 1100 °C showed optimal balance, reducing bacterial proliferation while supporting osteoblast growth. In vivo testing demonstrated angiogenesis stimulation without inflammation. MgO's dual effect makes this a promising antibacterial bone substitute.
Publisher
Scientific Reports
Published On
Nov 05, 2020
Authors
Catarina C. Coelho, Tatiana Padrão, Laura Costa, Marta T. Pinto, Paulo C. Costa, Valentina F. Domingues, Paulo A. Quadros, Fernando J. Monteiro, Susana R. Sousa
Tags
hydroxyapatite
magnesium oxide
bone substitute
antibacterial
osteoblast growth
angiogenesis
bone regeneration
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