Medicine and Health

The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice

Y. Wu, C. Chen, et al.

This groundbreaking study reveals how right-side anterior insular cortex (aIC) CamKII+ neurons respond to aversive visceral signals, influencing food intake in mice. The team, including Yu Wu and Changwan Chen, uncovers a neural circuit that plays a pivotal role in regulating feeding behavior, offering new insights into addressing reduced food intake in pathological conditions.

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Abstract

Reduced food intake is common in many pathological conditions. This study demonstrates that right-side anterior insular cortex (aIC) CamKII+ neurons in mice are activated by aversive visceral signals. Hyperactivation attenuates food consumption, while inhibition increases feeding and reverses anorexia. The right-side aICCamKII+-to-lateral hypothalamus pathway mediates feeding suppression, uncovering a circuit sensing aversive visceral signals and controlling feeding behavior.

Publisher

Nature Communications

Published On

Jan 31, 2020

Authors

Yu Wu, Changwan Chen, Ming Chen, Kai Qian, Xinyou Lv, Haiting Wang, Lifei Jiang, Lina Yu, Min Zhuo, Shuang Qiu

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