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The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice

Medicine and Health

The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice

Y. Wu, C. Chen, et al.

This groundbreaking study reveals how right-side anterior insular cortex (aIC) CamKII+ neurons respond to aversive visceral signals, influencing food intake in mice. The team, including Yu Wu and Changwan Chen, uncovers a neural circuit that plays a pivotal role in regulating feeding behavior, offering new insights into addressing reduced food intake in pathological conditions.

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Playback language: English
Abstract
Reduced food intake is common in many pathological conditions. This study demonstrates that right-side anterior insular cortex (aIC) CamKII+ neurons in mice are activated by aversive visceral signals. Hyperactivation attenuates food consumption, while inhibition increases feeding and reverses anorexia. The right-side aICCamKII+-to-lateral hypothalamus pathway mediates feeding suppression, uncovering a circuit sensing aversive visceral signals and controlling feeding behavior.
Publisher
Nature Communications
Published On
Jan 31, 2020
Authors
Yu Wu, Changwan Chen, Ming Chen, Kai Qian, Xinyou Lv, Haiting Wang, Lifei Jiang, Lina Yu, Min Zhuo, Shuang Qiu
Tags
food intake
visceral signals
brain circuitry
neuronal activation
anorexia management
feeding behavior
insular cortex

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