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Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils

Medicine and Health

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils

D. Jacek, I. Karagiannidis, et al.

This groundbreaking research conducted by Damian Jacek, Ioannis Karagiannidis, and Ellen J. Beswick explores how Th2 cells can inhibit the growth of colon and pancreas cancers. The study reveals that Th2 cells not only reduce tumor burden through apoptosis induction but also attract immune cells to fight cancer. With IL-5 administration showing similar effects, this study positions Th2 cells and IL-5 as promising therapeutic targets in fighting gastrointestinal cancers.

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Playback language: English
Abstract
This study investigates the role of Th2 cells in inhibiting the growth of colon and pancreas cancers. Using murine models, the researchers found that adoptive transfer of Th2 cells significantly reduced tumor burden. This effect was mediated by the induction of apoptotic factors and the recruitment of macrophages and eosinophils into the tumor microenvironment, where they produced cytotoxic factors. IL-5 hypersecretion, linked to the anti-tumorigenic function of Th2 cells and eosinophils, was also observed. Recombinant IL-5 administration similarly inhibited tumor growth. Both Th2 cells and eosinophils were directly responsible for cancer cell killing. The findings highlight the potential of Th2 cells and IL-5 as therapeutic targets in gastrointestinal cancers.
Publisher
British Journal of Cancer
Published On
Dec 28, 2022
Authors
Damian Jacek, Ioannis Karagiannidis, Ellen J. Beswick
Tags
Th2 cells
cancer inhibition
colon cancer
pancreas cancer
IL-5
tumor microenvironment
apoptosis
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