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Temperature-dependent differences in mouse gut motility are mediated by stress

Medicine and Health

Temperature-dependent differences in mouse gut motility are mediated by stress

A. Han, C. Hudson-paz, et al.

This fascinating study by Alvin Han and colleagues reveals how environmental temperature affects mouse gut motility, elucidating the role of stress pathways in this physiological response. Mice at lower temperatures exhibit a remarkable increase in gut transit speed, shedding light on the intricate relationship between temperature, stress, and gastrointestinal function.

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Playback language: English
Abstract
This study investigates the impact of environmental temperature on mouse gastrointestinal physiology, specifically gut motility. Mice raised at 22°C exhibit significantly faster whole gut transit time (WGTT) compared to those raised at 30°C (thermoneutrality). This difference is primarily due to a threefold increase in colon transit speed at 22°C. While gut microbiota composition differs between the two temperatures, it does not appear to be the primary driver of the motility difference. Instead, elevated stress signals from the hypothalamic-pituitary-adrenal (HPA) axis at 22°C play a crucial role. Pharmacological and genetic depletion of corticotropin-releasing hormone (CRH) slows gut motility in stressed 22°C mice but not in 30°C mice. The findings indicate that colder housing temperatures increase gut motility via HPA axis stress pathways.
Publisher
Lab Animal
Published On
Jun 01, 2024
Authors
Alvin Han, Courtney Hudson-Paz, Beatriz G. Robinson, Laren Becker, Amanda Jacobson, Julia A. Kaltschmidt, Jennifer L. Garrison, Ami S. Bhatt, Denise M. Monack
Tags
gut motility
environmental temperature
mouse physiology
hypothalamic-pituitary-adrenal axis
stress signals
gastrointestinal function

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