Accumulating senescent cells contribute to aging and age-related diseases. This study shows that a *Salvia haenkei* extract (Haenkenium, HK) extended lifespan and healthspan in aged mice. HK inhibited age-induced inflammation, fibrosis, and senescence markers, improving muscle strength and fur thickness. It also reduced doxorubicin-induced senescence. Luteolin, a flavonoid in HK, disrupted the p16–CDK6 interaction, suggesting a mechanism for senescence inhibition.

Sara Zumerle, Miles Sarill, Miriam Saponaro, Manuel Colucci, Liliana Contu, Edoardo Lazzarini, Roberta Sartori, Camilla Pezzini, Anna Rinaldi, Anna Scanu, Jacopo Sgrignani, Patrizia Locatelli, Marianna Sabbadin, Aurora Valdata, Daniela Brina, Isabella Giacomini, Beatrice Rizzo, Alessandra Pierantoni, Saman Sharifi, Silvia Bressan, Claudia Altomare, Yulia Goshovska, Chiara Giraudo, Roberto Luisetto, Luca Iaccarino, Cristina Torcasio, Simone Mosole, Emiliano Pasquini, Andrea Rinaldi, Laura Pellegrini, Gregorio Peron, Matteo Fassan, Stefano Masiero, Andrea Maria Giori, Stefano Dall’Acqua, Johan Auwerx, Pietro Cippà, Andrea Cavalli, Marco Bolis, Marco Sandri, Lucio Barile, Monica Montopoli, Andrea Alimonti