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α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

Medicine and Health

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

C. S. L. Arlehamn, R. Dhanwani, et al.

This groundbreaking study reveals that α-synuclein-specific T cell responses may be present long before the clinical diagnosis of Parkinson's disease. Conducted by Cecilia S. Lindestam Arlehamn and team, the research indicates a significant correlation between these immune responses and motor diagnosis, paving the way for potential early detection and understanding of disease pathogenesis.

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Playback language: English
Abstract
This study examined the temporal relationship between α-synuclein (α-syn)-specific T cell reactivity and Parkinson's disease (PD). A longitudinal case study showed elevated α-syn-specific T cell responses before motor PD diagnosis, declining afterward. Two independent cohorts confirmed highest α-syn-specific T cell responses shortly after motor PD diagnosis, decreasing thereafter. These responses correlated with age and lower levodopa equivalent dose. The findings suggest α-syn-reactive T cells are present years before motor PD diagnosis, potentially impacting pathogenesis and early diagnosis.
Publisher
Nature Communications
Published On
Apr 20, 2020
Authors
Cecilia S. Lindestam Arlehamn, Rekha Dhanwani, John Pham, Rebecca Kuan, April Frazier, Juliana Rezende Dutra, Elizabeth Phillips, Simon Mallala, Mario Roederer, Karen S. Marder, Amy V. Amara, David G. Standaert, Jennifer G. Goldman, Irene Litvan, Bjoern Peters, David Sulzer, Alessandro Sette
Tags
Parkinson's disease
α-synuclein
T cell reactivity
early diagnosis
pathogenesis

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