The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). This study quantifies SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity. Higher SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower lymphocyte counts, increased inflammation markers (CRP and IL-6), and increased mortality risk. The data suggest that SARS-CoV-2 viral load may aid in COVID-19 patient risk stratification.
Publisher
NATURE COMMUNICATIONS
Published On
Oct 30, 2020
Authors
Jesse Faijnzlyber, James Regan, Kendyll Coxen, Heather Corry, Colline Wong, Alexandra Rosenthal, Daniel Worrall, Francoise Gigue, Alicja Piechocka-TTrocha, Caroline Atyeo, Stephanie Fischinger, Andrew Chua, Keith T. Flaherty, Kathryn Hall, Michael Dougan, Edward T. Ryan, Elizabeth Gillespie, Rida Chishti, Yijia Li, Nikolaus Jilg, Dusan Handiziar, Rebecca M. Baron, Lindsey Baden, Athe M. Tsibris, Katrina A. Armstrong, Daniel R. Kuritzkes, Galit Alter, Bruce D. Walker, Xu Yu, Jonathan Z. Liu
Tags
SARS-CoV-2
viral load
COVID-19
disease progression
mortality
risk stratification
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