This research paper explores synthetic virology approaches to enhance the safety and efficacy of oncolytic virus therapies. The authors adapt drug-controlled gene switches to control viral replication and transgene expression in vaccinia virus vectors. They rationally design synthetic promoters for robust inducible expression and generate chimeric synthetic promoters for additional regulatory layers. These systems are applied to modulate transgene expression, enabling precise control of oncolytic virus behavior, ultimately improving safety and efficacy in vivo.
Publisher
Nature Communications
Published On
May 26, 2023
Authors
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abdolrafat Nik-Aktar, Mahsa Ahmad, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell
Tags
synthetic virology
oncolytic virus therapies
viral replication
transgene expression
gene switches
promoters
cancer treatment
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