Medicine and Health

Symptomatic COVID-19 course and outcomes after three mRNA vaccine doses in multiple sclerosis patients treated with high-efficacy DMTs

R. Capuano, L. Prosperini, et al.

This study investigated the impact of a third mRNA vaccine dose on COVID-19 outcomes in multiple sclerosis patients treated with ocrelizumab, fingolimod, and natalizumab. The research, conducted by Rocco Capuano and colleagues, found that while some differences in COVID-19 symptoms and hospitalization rates existed among treatments, no deaths occurred, and the booster dose showed effectiveness against severe COVID-19.

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Abstract

This study evaluated COVID-19 course and outcomes in multiple sclerosis (MS) patients treated with ocrelizumab (OCR), fingolimod (FNG), or natalizumab (NTZ) after a third mRNA vaccine dose. 290 patients from 17 Italian MS centers were included. While those on OCR and FNG showed slightly more symptomatic COVID-19 and higher hospitalization rates than those on NTZ, regression models indicated that most differences weren't due to DMTs. No deaths occurred. The study supports the third booster dose's effectiveness against severe COVID-19 in MS patients on OCR and FNG.

Publisher

Multiple Sclerosis Journal

Published On

Mar 29, 2023

Authors

Rocco Capuano, Luca Prosperini, Manuela Altieri, Lorena Lorefice, Roberta Fantozzi, Paola Cavalla, Clara Guaschino, Marta Radaelli, Cinzia Cordioli, Viviana Nociti, Laura Boffa, Paolo Ragonese, Maria Di Gregorio, Federica Pinardi, Valentina Torri Clerici, Giovanna De Luca, Alberto Gajofatto, Damiano Paolicelli, Carla Tortorella, Claudio Gasperini, Claudio Solaro, Eleonora Cocco, Alvino Bisecco, Antonio Gallo, Giovanni Di Dio

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