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Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Biology

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

W. Kao, C. O. D. P. Northumberland, et al.

Discover how proton-translocating respiratory complexes in *Corynebacterium glutamicum* form supercomplexes for efficient energy conversion while limiting harmful reactive oxygen species. This research, conducted by an expert team including Wei-Chun Kao and Claire Ortmann de Percin Northumberland, unveils critical structures for potential drug design against actinobacteria.

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Playback language: English
Abstract
Proton-translocating respiratory complexes assemble into supercomplexes to increase energy conversion efficiency and limit reactive oxygen species. This study uses 2.8 Å resolution cryo-EM to reveal the cytochrome bcc-aa3 (III2-IV2) supercomplex structure from *Corynebacterium glutamicum*, resolving menaquinone, substrate mimics, lycopene, an unexpected Qo site, dioxygen, proton transfer routes, and key residue conformations. The structure elucidates how safe and efficient energy conversion is achieved through controlled electron and proton transfer, potentially guiding drug design against actinobacteria.
Publisher
Nature Communications
Published On
Jan 27, 2022
Authors
Wei-Chun Kao, Claire Ortmann de Percin Northumberland, Tat Cheung Cheng, Julio Ortiz, Alexandre Durand, Ottilie von Loeffelholz, Oliver Schilling, Martin L. Biniossek, Bruno P. Klaholz, Carola Hunte
Tags
proton transfer
energy conversion
supercomplexes
Corynebacterium glutamicum
reactive oxygen species
electron transfer
drug design

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