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Sterile protection against relapsing malaria with a single-shot vaccine

Medicine and Health

Sterile protection against relapsing malaria with a single-shot vaccine

E. M. Pasini, A. V. V. D. Wel, et al.

This groundbreaking study by Erica M. Pasini and colleagues explores a novel single-shot vaccine strategy for *Plasmodium vivax*, demonstrating fascinating results with 75% sterile protection in a rhesus macaque model. The research points towards a potential breakthrough in malaria vaccination that hinges on self-boosting immune responses.

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Playback language: English
Abstract
Development of a vaccine for *Plasmodium vivax*, a relapsing malaria parasite, lags behind that for *P. falciparum*. This study used the *P. cynomolgi*-rhesus macaque model to test a single-shot, high-dose live sporozoite vaccination approach. The natural relapsing phenotype of the parasite was leveraged to self-boost the immune response. Results showed sterile protection in 75% of animals with limited blood-stage exposure, suggesting that controlled blood-stage exposure might enhance protection. This proof-of-concept study indicates a potential new direction for *P. vivax* vaccine development.
Publisher
npj Vaccines
Published On
Nov 16, 2022
Authors
Erica M. Pasini, Annemarie Voorberg van der Wel, Nicole Heijmans, Onny Klop, Anne-Marie Zeeman, Herman Oostermeijer, Ivonne Neurdenburg, Roberto Rodríguez García, Nicole Onur van der Werff, Sam O. Hofman, Frank A. W. Verreck, Edmond J. Remarque, Bart W. Faber, Clemens H. M. Kocken
Tags
Plasmodium vivax
vaccine development
malaria
immune response
single-shot vaccination
rhesus macaque
sterile protection

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