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Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation

Chemistry

Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation

F. Wang, Z. Zhang, et al.

Discover a groundbreaking method for synthesizing 3,4-disubstituted succinimides using a dynamic kinetic resolution strategy. This innovative approach, championed by researchers Fangyuan Wang and colleagues, leverages a highly active Rh catalyst to achieve remarkable enantioselectivity and diastereoselectivity, providing separate access to *syn*- and *anti*-configured products. Embrace the future of enantioenriched succinimides with this stereodivergent technique!

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