Medicine and Health

Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation

F. Ellermann, A. Sirbu, et al.

Discover the groundbreaking advancements in automated parahydrogen-induced hyperpolarization (PHIP) presented by Frowin Ellermann, Aidan Sirbu, Arne Brahms, Charbel Assaf, Rainer Herges, Jan-Bernd Hövener, and Andrey N. Pravdivtsev. Their innovative polarizer operates at 0.5 T, providing highly efficient hyperpolarization for diverse applications, including reaction monitoring and in vivo metabolic imaging.

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Abstract

This paper presents a portable, automated parahydrogen-induced hyperpolarization (PHIP) polarizer operating at 0.5 T, achieving high hyperpolarization of various molecules. The system's automation, compact design, and use of a benchtop MRI scanner enable efficient and reproducible hyperpolarization for applications in reaction monitoring and in vivo metabolic imaging.

Publisher

Nature Communications

Published On

Aug 08, 2023

Authors

Frowin Ellermann, Aidan Sirbu, Arne Brahms, Charbel Assaf, Rainer Herges, Jan-Bernd Hövener, Andrey N. Pravdivtsev

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