Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Spermidine, a naturally occurring polyamine, exhibits remarkable anticancer properties by interfering with the tumor cell cycle, inhibiting proliferation, suppressing growth, and triggering autophagy. Its role in anticancer immunosurveillance and regulation of polyamine metabolism further contributes to tumor suppression. Spermidine/spermine N-1acetyltransferase (SSAT) is crucial for polyamine homeostasis and serves as a diagnostic marker in cancers. Chemically modified spermidine derivatives show promise for prognostic, diagnostic, and therapeutic applications. This review details recent findings supporting spermidine's anticancer mechanisms and molecular physiology.

Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Monica Gulati, Dinesh Kumar Chellappan, Rashi Rajput, Gaurav Gupta, Alibek Ydyrys, Marzhan Kulbayeva, Ahmad Faizal, Abdull Razis, Babagana Modu, Javad Sharifi-Rad, Kamal Dua