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Abstract
Sperm selection is crucial for assisted reproductive treatments (ARTs). Conventional methods like swim-up (SU) can induce DNA fragmentation. This study introduces a 3D-printed microfluidic sperm selection platform (MSSP) that mimics sperm's natural journey. MSSP selects sperm based on motility, boundary-following behavior, and apoptotic marker expression. Compared to SU, MSSP yielded 68% more motile sperm with less DNA fragmentation and apoptosis. MSSP sperm also showed higher motility post-cryopreservation. Using human semen (n=33), MSSP showed an 85% improvement in DNA integrity and a 90% reduction in sperm apoptosis compared to SU.
Publisher
Microsystems & Nanoengineering
Published On
Jan 28, 2023
Authors
Steven A. Vasilescu, Lin Ding, Farin Yazdan Parast, Reza Nosrati, Majid Ebrahimi Warkiani
Tags
sperm selection
3D-printed microfluidics
assisted reproductive treatments
DNA fragmentation
motility
apoptosis
cryopreservation

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