Psychology

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

K. J. Clancy, Q. Devignes, et al.

Explore how trauma-related intrusive memories (TR-IMs) uniquely affect the brain! This exciting research, conducted by Kevin J. Clancy and colleagues, reveals fascinating neural mechanisms linked to emotional intensity, sensory features, and the experience of reliving trauma, providing new insights for personalized treatment approaches.

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Playback language: English

Index

Abstract

Trauma-related intrusive memories (TR-IMs) are a significant challenge in treating post-traumatic sequelae. This study investigated the neural mechanisms of TR-IMs' unique phenomenological properties in 84 trauma-exposed adults using ecological momentary assessments (EMAs) and resting-state fMRI. Emotional intensity was inversely associated with anterior hippocampal (aHPC)-default mode network (DMN) co-activation. Sensory features correlated with HPC-sensory cortex and ventral attention network co-activation, while reliving was linked to persistent pHPC-visual cortex co-activation. Importantly, no associations were found with conventional symptom measures, highlighting the value of EMAs. These findings offer insights into the neural basis of TR-IMs, crucial for developing individualized treatments.

Publisher

Molecular Psychiatry

Published On

Mar 07, 2024

Authors

Kevin J. Clancy, Quentin Devignes, Boyu Ren, Yara Pollmann, Sienna R. Nielsen, Kristin Howell, Poornima Kumar, Emily L. Belleau, Isabelle M. Rosso

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