Medicine and Health

Sleep-like cortical dynamics during wakefulness and their network effects following brain injury

M. Massimini, M. Corbetta, et al.

This paper introduces a novel framework linking classical and recent ideas to show that EEG slow waves after brain injury reflect the intrusion of sleep-like cortical dynamics during wakefulness, explains how these dynamics can disrupt functional networks and behavior, and outlines how modulating post-injury slow waves could reawaken sleeping brain regions to optimize rehabilitation — research conducted by Marcello Massimini, Maurizio Corbetta, Maria V. Sanchez-Vives, Thomas Andrillon, Gustavo Deco, Mario Rosanova, and Simone Sarasso.

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~3 min • Beginner • English

Index

Abstract

By connecting old and recent notions, different spatial scales, and research domains, we introduce a novel framework on the consequences of brain injury focusing on a key role of slow waves. We argue that the long-standing finding of EEG slow waves after brain injury reflects the intrusion of sleep-like cortical dynamics during wakefulness; we illustrate how these dynamics are generated and how they can lead to functional network disruption and behavioral impairment. Finally, we outline a scenario whereby post-injury slow waves can be modulated to reawaken parts of the brain that have fallen asleep to optimize rehabilitation strategies and promote recovery.

Publisher

Nature Communications

Published On

Aug 22, 2024

Authors

Marcello Massimini, Maurizio Corbetta, Maria V. Sanchez-Vives, Thomas Andrillon, Gustavo Deco, Mario Rosanova, Simone Sarasso

DOI

https://doi.org/10.1038/s41467-024-51586-1

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