ChemistryNature Chemical Biology
Site-specific encoding of photoactivity and photoreactivity into antibody fragments
T. Bridge, U. Wegmann, et al.
This innovative research led by Thomas Bridge and colleagues introduces a groundbreaking method to activate EGFR-targeting antibody fragments using light. By incorporating photocaged tyrosine and p-benzoyl-L-phenylalanine, the engineered fragment only binds EGFR upon exposure to 365-nm light, promising exciting applications in targeted therapies.
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