Medicine and HealthCommunications Biology
Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease
G. Novak, D. Kyriakis, et al.
Explore the groundbreaking findings from a study by Gabriela Novak and colleagues, which reveals a converging network for Parkinson's disease pathways using midbrain dopaminergic neurons derived from human induced pluripotent stem cells. This research uncovers significant alterations in gene expression and dopamine metabolism, potentially enhancing our understanding of the disease's phenotypic heterogeneity.
Related Publications
Explore these studies to deepen your understanding
Adjacent work that informs or extends this paper's methodology and findings.
Medicine and Health
HIDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data
A. Goeva, M. Dolan, et al.
Medicine and Health
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease
T. Kamath, A. Abdulraouf, et al.
Medicine and Health
Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea
M. Chen, L. Yang, et al.
Medicine and Health
Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics
B. Hadland, B. Varnum-finney, et al.
