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Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex
Medicine and HealthNature Communications

Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex

R. Ogelman, L. E. G. Wulschner, et al.

Serotonin release in the early postnatal prefrontal cortex bidirectionally sculpts excitatory spine density and strength: single-spine 5-HT triggers structural and functional LTP via 5-HT2A and 5-HT7 receptors and promotes long-term survival of new spines, while early-life fluoxetine mimics these synaptic enhancements—effects blocked by 5-HT2A/5-HT7 antagonists. Research conducted by Roberto Ogelman, Luis E. Gomez Wulschner, Victoria M. Hoelscher, In-Wook Hwang, Victoria N. Chang, and Won Chan Oh.... show more
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