Medicine and Health

Serial monitoring of circulating tumour DNA on clinical outcome in myelodysplastic syndromes and acute myeloid leukaemia

X. Zhou, W. Lang, et al.

This groundbreaking study by Xinping Zhou and colleagues reveals that circulating tumor DNA (ctDNA) is a promising minimally invasive biomarker for monitoring treatment outcomes in myelodysplastic syndromes and acute myeloid leukemia. The findings highlight the significant correlation between ctDNA concentrations and tumor burden, underscoring its potential in predicting patient survival and detecting early relapses.

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Abstract

This study assessed the feasibility and utility of circulating tumor DNA (ctDNA) as a minimally invasive biomarker for monitoring treatment outcome, tracking clonal evolution, and predicting survival in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The researchers found a strong correlation between pre-treatment ctDNA concentrations and bone marrow blasts, indicating a relationship to tumor burden. Post-treatment ctDNA positivity was associated with shorter progression-free survival (PFS) and overall survival (OS). Changes in ctDNA VAF and concentration were effective prognostic biomarkers. The study also observed clonal evolution patterns in refractory/relapsed cases, demonstrating ctDNA's potential for early relapse detection.

Publisher

Clinical and Translational Medicine

Published On

Jul 20, 2023

Authors

Xinping Zhou, Wei Lang, Chen Mei, Yanling Ren, Liya Ma, Lingxu Jiang, Li Ye, Gaixiang Xu, Yingwan Luo, Lixia Liu, Shanbo Cao, Jiayue Qin, Hongyan Tong

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