This study investigates the neural mechanisms underlying fear generalization in trauma-exposed individuals with and without psychopathology. Using a generalization fMRI task, researchers compared trauma-exposed participants (TE) with healthy controls (HC), and resilient trauma-exposed participants (TEHC) with trauma-exposed individuals with psychopathology (TEPG). TE participants showed lower activity reduction in the salience network (SN) and right executive control network (RECN) and worse discrimination learning in SN. TEHC showed a resilience signature in RECN connectivity during generalization learning. These findings may inform the development of targeted treatments for trauma-related neural dysfunction.
Publisher
Communications Biology
Published On
Nov 21, 2022
Authors
Xi Zhu, Benjamin Suarez-Jimenez, Amit Lazarov, Sara Such, Caroline Marohasy, Scott S. Small, Tor D. Wager, Martin A. Lindquist, Shmuel Lissek, Yuval Neria
Tags
fear generalization
trauma
psychopathology
neural mechanisms
resilience
fMRI
treatment
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