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Self-reporting photodynamic nanobody conjugate for precise and sustainable large-volume tumor treatment

Medicine and Health

Self-reporting photodynamic nanobody conjugate for precise and sustainable large-volume tumor treatment

Y. Chen, T. Xiong, et al.

Discover the innovative development of MNB-Pyra Nbs, a groundbreaking photodynamic conjugate that effectively suppresses tumors. This pioneering research by Yingchao Chen, Tao Xiong, Qiang Peng, Jianjun Du, Wen Sun, Jiangli Fan, and Xiaojun Peng showcases how these photosensitizers can be activated for self-reporting PDT, making a significant impact in cancer therapy.

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Playback language: English
Abstract
This paper presents the development of photodynamic conjugates, MNB-Pyra Nbs, through site-specific conjugation between 7D12 Nbs and type I photosensitizer MNB-Pyra. The photosensitizers exhibit long-term retention, are released at the tumor site by reactive oxygen species cleavage after illumination, and display fluorescence recovery for self-reporting PDT. A single dose of MNB-Pyra Nbs demonstrates effective tumor suppression in large-volume tumor models after three rounds of PDT.
Publisher
Nature Communications
Published On
Aug 13, 2024
Authors
Yingchao Chen, Tao Xiong, Qiang Peng, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng
Tags
photodynamic therapy
MNB-Pyra Nbs
tumor suppression
site-specific conjugation
reactive oxygen species
fluorescence recovery
cancer treatment

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