Self-reporting photodynamic nanobody conjugate for precise and

Index

Abstract

This paper presents the development of photodynamic conjugates, MNB-Pyra Nbs, through site-specific conjugation between 7D12 Nbs and type I photosensitizer MNB-Pyra. The photosensitizers exhibit long-term retention, are released at the tumor site by reactive oxygen species cleavage after illumination, and display fluorescence recovery for self-reporting PDT. A single dose of MNB-Pyra Nbs demonstrates effective tumor suppression in large-volume tumor models after three rounds of PDT.

Publisher

Nature Communications

Published On

Aug 13, 2024

Authors

Yingchao Chen, Tao Xiong, Qiang Peng, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng

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