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Abstract
This research presents a novel magnesium (Mg₃)·Fe₃O₄-based Magneto-Fluorescent Nanorobot (“MFN”) that self-propels in blood, enabling selective and rapid isolation of cancer cells. The nanobots, modified with EpCAM antibody/transferrin, cyanine 5 dye, G4 dendrimers, and glutathione, demonstrate nearly 100% cancer cell capture efficiency in serum and whole blood, particularly with MCF7 breast cancer cells. The self-propulsion in water, combined with the Fe₃O₄ shell for magnetic guidance, significantly improves sensitivity, efficiency, and speed of cancer cell capture.
Publisher
COMMUNICATIONS CHEMISTRY
Published On
Nov 15, 2021
Authors
Ravindra D. Wavhale, Kshama D. Dhobale, Chinmay S. Rahane, Govind P. Chate, Bhaushaeb V. Tawade, Yuvraj N. Patil, Sandesh S. Gawade, Shashwat S. Banerjee
Tags
Magneto-Fluorescent Nanorobot
cancer cell isolation
self-propulsion
EpCAM antibody
MCF7 breast cancer cells
Fe₃O₄ shell
capture efficiency

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