Medicine and Health

Water-powered self-propelled magnetic nanobot for rapid and highly efficient capture of circulating tumor cells

R. D. Wavhale, K. D. Dhobale, et al.

Discover a groundbreaking magnesium·Fe₃O₄-based Magneto-Fluorescent Nanorobot that self-propels in blood, enabling the nearly perfect isolation of cancer cells. Developed by Ravindra D. Wavhale and team at the Maharashtra Institute of Medical Education and Research, this innovative technology shows exceptional efficiency in capturing cancer cells, particularly MCF7 breast cancer cells, in serum and whole blood.

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Abstract

This research presents a novel magnesium (Mg₃)·Fe₃O₄-based Magneto-Fluorescent Nanorobot (“MFN”) that self-propels in blood, enabling selective and rapid isolation of cancer cells. The nanobots, modified with EpCAM antibody/transferrin, cyanine 5 dye, G4 dendrimers, and glutathione, demonstrate nearly 100% cancer cell capture efficiency in serum and whole blood, particularly with MCF7 breast cancer cells. The self-propulsion in water, combined with the Fe₃O₄ shell for magnetic guidance, significantly improves sensitivity, efficiency, and speed of cancer cell capture.

Publisher

COMMUNICATIONS CHEMISTRY

Published On

Nov 15, 2021

Authors

Ravindra D. Wavhale, Kshama D. Dhobale, Chinmay S. Rahane, Govind P. Chate, Bhaushaeb V. Tawade, Yuvraj N. Patil, Sandesh S. Gawade, Shashwat S. Banerjee

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