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Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer

Medicine and Health

Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer

C. Cointe, A. Laborde, et al.

Discover the innovative scalable batch fabrication technique behind ultrathin and flexible neural probes developed by Clement Cointe, Adrian Laborde, Lionel G. Nowak, Dina N. Arvanitis, David Bourrier, Christian Bergaud, and Ali Maziz. These remarkable probes facilitate high-fidelity recordings of epileptic seizures and neuron activity, revolutionizing the field of neural interfacing.

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Playback language: English
Abstract
This paper presents a novel scalable batch fabrication approach for ultrathin and flexible neural probes. The probes consist of a silk-parylene bilayer, where the biodegradable silk layer acts as a temporary stiffener for insertion, enabling the use of ultrathin parylene-based flexible devices. This method allows for control over probe design and has shown successful ex vivo insertion with high-fidelity recordings of epileptic seizures and single-unit action potentials in mouse brain slices.
Publisher
Microsystems & Nanoengineering
Published On
Jan 28, 2022
Authors
Clement Cointe, Adrian Laborde, Lionel G. Nowak, Dina N. Arvanitis, David Bourrier, Christian Bergaud, Ali Maziz
Tags
neural probes
batch fabrication
silk-parylene bilayer
flexible devices
high-fidelity recordings
epileptic seizures
biodegradable

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