Chemistry

Ru(II) photocages enable precise control over enzyme activity with red light

D. Havrylyuk, A. C. Hachey, et al.

Discover groundbreaking research by Dmytro Havrylyuk, Austin C. Hachey, Alexander Fenton, David K. Heidary, and Edith C. Glazer on light-triggered CYP1B1 inhibitors that significantly improve cancer chemotherapy resistance. With a staggering 6000-fold potency enhancement upon activation, these novel prodrugs showcase exceptional selectivity, paving the way for innovative treatments in medicinal chemistry.... show more

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