BiologyeLife
Reward contingency gates selective cholinergic suppression of amygdala neurons
E. Y. Kimchi, A. Burgos-robles, et al.
Basal forebrain cholinergic neurons drive conditioned reward-seeking: they fire during learned licking even before reward delivery and without external cues; photostimulation of these neurons or their basolateral amygdala terminals enhances conditioned responding but not unconditioned or innate actions; in vivo and ex vivo data show reward-contingency-dependent suppression of BLA projection neurons via monosynaptic muscarinic signaling and facilitation of BLA interneurons. Research conducted by Eyal Y Kimchi, Anthony Burgos-Robles, Gillian A Matthews, Tatenda Chakoma, Makenzie Patarino, Javier C Weddington, Cody Siciliano, Wannan Yang, Shaun Foutch, Renee Simons, Ming-fai Fong, Miao Jing, Yulong Li, Daniel B Polley, and Kay M Tye.
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