Psychology

Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency

S. J. Millard, I. B. Hoang, et al.

This exciting study by Samuel J. Millard and colleagues delves into the fascinating world of intracranial self-stimulation (ICSS) of midbrain dopamine neurons, revealing how different stimulation frequencies affect reward motivation! Discover how a physiological prediction error at 20 Hz contrasts sharply with the robust motivational effects of 50 Hz stimulation on behavior.

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Index

Abstract

This study investigates the cognitive representations underlying intracranial self-stimulation (ICSS) of midbrain dopamine neurons. 20-Hz stimulation, approximating a physiological prediction error, was insufficient to support ICSS beyond a continuous reinforcement schedule and did not endow cues with value. However, 50-Hz stimulation drove robust ICSS and was represented as a specific reward, motivating behavior. This frequency dependence stems from the rate, not number, of action potentials, differentially modulating dopamine release.

Publisher

Nature Neuroscience

Published On

Jul 01, 2024

Authors

Samuel J. Millard, Ivy B. Hoang, Savannah Sherwood, Masakazu Taira, Vanessa Reyes, Zara Greer, Shayna L. O'Connor, Kate M. Wassum, Morgan H. James, David J. Barker, Melissa J. Sharpe

DOI

https://doi.org/10.1038/s41593-024-01643-1

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