Biology

Review-Key Symposium

L. Smulders and J. Deelen

Explore the intriguing genetic components of human longevity as highlighted by Larissa Smulders and Joris Deelen. This review delves into key pathways that contribute to a longer life, including insulin signaling and telomere maintenance. Discover the future directions in longevity research that could reshape our understanding of aging.

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Playback language: English

Index

Abstract

The increasing lifespan without a corresponding increase in healthspan presents a significant challenge. This review explores the genetic components of human longevity, focusing on studies with well-defined populations. It highlights five consistently longevity-associated pathways: (1) insulin/IGF-1 signaling, (2) DNA damage response and repair, (3) immune function, (4) cholesterol metabolism, and (5) telomere maintenance. Future research should prioritize identifying and functionally characterizing rare genetic variants within these pathways.

Publisher

Journal of Internal Medicine

Published On

Jan 01, 2024

Authors

Larissa Smulders, Joris Deelen

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