The increasing lifespan without a corresponding increase in healthspan presents a significant challenge. This review explores the genetic components of human longevity, focusing on studies with well-defined populations. It highlights five consistently longevity-associated pathways: (1) insulin/IGF-1 signaling, (2) DNA damage response and repair, (3) immune function, (4) cholesterol metabolism, and (5) telomere maintenance. Future research should prioritize identifying and functionally characterizing rare genetic variants within these pathways.
Publisher
Journal of Internal Medicine
Published On
Jan 01, 2024
Authors
Larissa Smulders, Joris Deelen
Tags
longevity
genetics
healthspan
aging
DNA repair
immune function
cholesterol metabolism
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