Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery

The dynamic protein corona formed on nanocarriers significantly affects their *in vivo* behaviors. This study explores the role of glycosylated polyhydroxy polymer-modified nanovesicles (CP-LVs) with varying amino/hydroxyl ratios in protein corona formation. CP-LVs with an amino/hydroxyl ratio of approximately 0.4 (CP₁-LVs) effectively suppress immunoglobulin adsorption, leading to prolonged circulation. CP₁-LVs also adsorb tumor-specific proteins, mediating selective tumor cell internalization. Paclitaxel-loaded CP₁-LVs demonstrate superior antitumor efficacy compared to PEGylated liposomes. This research suggests a new approach for nanocarrier surface design to modulate protein corona formation for improved drug delivery.

Yunqiu Miao, Lijun Li, Ying Wang, Jiangyue Wang, Yihan Zhou, Linmiao Guo, Yanqi Zhao, Di Nie, Yang Zhang, Xinxin Zhang, Yong Gan