Medicine and Health

Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

E. Randrianarisoa, A. Lehn-stefan, et al.

This study explores the intriguing link between glycemic traits and carotid intima-media thickness (cIMT), revealing that reduced insulin clearance correlates with early signs of vascular damage. Conducted by a team of researchers from the Institute of Diabetes Research and Metabolic Diseases and the University Hospital of Tübingen, it sheds light on potential early markers for those at risk of type 2 diabetes.

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Abstract

This cross-sectional study investigated the relationship between glycemic traits and carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, in individuals at increased risk for type 2 diabetes mellitus (T2D). Reduced insulin clearance was significantly associated with increased cIMT in univariate and multivariate analyses, independent of traditional cardiovascular disease risk factors. This suggests that reduced insulin clearance may be an early marker of vascular damage.

Publisher

Scientific Reports

Published On

Dec 31, 2020

Authors

Elko Randrianarisoa, Angela Lehn-Stefan, Anja Hieronymus, Robert Wagner, Jakub Machuzak, Kilian Rittig, Bernd Balletshofer, Andreas L. Birkenfeld, Andreas Peter, Norbert Stefan, Hans-Ulrich Häring, Martin Heni

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