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Reconstituting the complete biosynthesis of D-lysergic acid in yeast
Medicine and HealthNature Communications

Reconstituting the complete biosynthesis of D-lysergic acid in yeast

G. Wong, L. R. Lim, et al.

This groundbreaking research, conducted by Garrett Wong, Li Rong Lim, Yong Quan Tan, Maybelle Kho, David J. Bell, Paul S. Freemont, and Wen Shan Yew, unveils a revolutionary way to produce D-lysergic acid, a vital precursor for ergot alkaloids used in treating neurological disorders, using engineered yeast. This approach not only simplifies the production process but also enhances efficiency, achieving a promising yield in a bioreactor setting.... show more
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