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Reconstituting the complete biosynthesis of D-lysergic acid in yeast

Medicine and Health

Reconstituting the complete biosynthesis of D-lysergic acid in yeast

G. Wong, L. R. Lim, et al.

This groundbreaking research, conducted by Garrett Wong, Li Rong Lim, Yong Quan Tan, Maybelle Kho, David J. Bell, Paul S. Freemont, and Wen Shan Yew, unveils a revolutionary way to produce D-lysergic acid, a vital precursor for ergot alkaloids used in treating neurological disorders, using engineered yeast. This approach not only simplifies the production process but also enhances efficiency, achieving a promising yield in a bioreactor setting.

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Playback language: English
Abstract
This work reports the production of D-lysergic acid (DLA), a key precursor for ergot alkaloids used in treating neurological ailments, in yeast. Current chemical synthesis methods are lengthy and inefficient, while fungal production methods result in complex product mixtures and strain degradation. The study demonstrates proof-of-concept for DLA production in engineered yeast from sugar, achieving a titer of 1.7 mg L⁻¹ in a 1L bioreactor.
Publisher
Nature Communications
Published On
Jul 26, 2021
Authors
Garrett Wong, Li Rong Lim, Yong Quan Tan, Maybelle Kho, David J. Bell, Paul S. Freemont, Wen Shan Yew
Tags
D-lysergic acid
ergot alkaloids
neurological ailments
yeast production
biotechnology
synthetic biology

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