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Real-time 31P NMR reveals different gradient strengths in polyphosphoester copolymers as potential MRI-traceable nanomaterials

Chemistry

Real-time 31P NMR reveals different gradient strengths in polyphosphoester copolymers as potential MRI-traceable nanomaterials

T. Rheinberger, U. Flögel, et al.

Discover the groundbreaking research on polyphosphoesters (PPEs) conducted by Timo Rheinberger, Ulrich Flögel, Olga Koshkina, and Frederik R. Wurm. This study explores the copolymerization of PPE subclasses, revealing their potential in creating gradient copolymers for applications in drug delivery and MRI tracking. Dive into the world of innovative nanomaterials that can revolutionize therapeutic technologies.

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Playback language: English
Abstract
Polyphosphoesters (PPEs) are versatile polymers with applications in tissue engineering, drug delivery, and materials science. This study systematically investigates the copolymerization of different PPE subclasses (side-chain and in-chain phosphonates, phosphates, and thiophosphates) using organocatalysis. Reactivity ratios were determined for binary and ternary copolymers, revealing gradient copolymers with tunable amphiphilicity and microstructure. These copolymers self-assembled into nanostructures in aqueous solutions, and 31P MRI imaging confirmed their potential as MRI-traceable nanomaterials, expanding their possibilities for drug delivery and theranostics.
Publisher
Communications Chemistry
Published On
Jan 26, 2023
Authors
Timo Rheinberger, Ulrich Flögel, Olga Koshkina, Frederik R. Wurm
Tags
polyphosphoesters
copolymerization
organocatalysis
drug delivery
MRI nanomaterials
tissue engineering
amphiphilicity

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