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Rapidly photocurable silk fibroin sealant for clinical applications

Medicine and Health

Rapidly photocurable silk fibroin sealant for clinical applications

S. H. Kim, Y. J. Lee, et al.

Introducing Sil-MAS, a revolutionary methacrylated silk fibroin sealant that addresses the common shortcomings of medical glues. Developed by a dedicated team of researchers, including Soon Hee Kim and Young Jin Lee, Sil-MAS demonstrates rapid crosslinking, excellent adhesion, and biocompatibility, making it an outstanding solution for enhanced wound healing in surgical applications.

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Playback language: English
Abstract
This paper introduces a methacrylated silk fibroin sealant (Sil-MAS) designed to overcome limitations of existing medical glues, such as biocompatibility issues, slow crosslinking times, and low adhesion. Sil-MAS exhibits rapid crosslinking, high adhesion, and biocompatibility, as demonstrated through in vitro and ex vivo tests. In vivo studies in rats showed excellent hemostatic and adhesive capabilities, promoting faster wound healing than commercial alternatives. A proof-of-concept laparoscopic application in a rabbit model further highlights Sil-MAS's potential as a versatile medical glue for various surgical procedures.
Publisher
NPG Asia Materials
Published On
Jan 30, 2020
Authors
Soon Hee Kim, Young Jin Lee, Janet Ren Chao, Do Yeon Kim, Md. Tipu Sultan, Ho Jun Lee, Jung Min Lee, Ji Seung Lee, Ok Joo Lee, Heesun Hong, Hanna Lee, Olatunji Ajiteru, Ye Ji Suh, Hak Soo Choi, Yong-Jun Cho, Chan Hum Park
Tags
methacrylated silk fibroin
medical glue
biocompatibility
wound healing
surgical applications
hemostatic capabilities
crosslinking

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