Medicine and Health

Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

S. Marot, I. Malet, et al.

A study conducted by Stéphane Marot and colleagues reveals alarming insights into neutralizing antibodies among SARS-CoV-2-infected healthcare workers. With data from 26 individuals, the researchers observed a significant decline in antibody levels over time, underscoring the need for ongoing infection prevention strategies and potential booster vaccinations.

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Abstract

Limited data exists on the persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). This study followed 26 HCW with mild COVID-19, assessing NAbs at three time points. A significant decrease in NAb titers was observed over time, correlating with a decline in systemic IgA antibody levels. This short-lived humoral protection highlights the need for continued infection prevention measures and potential periodic vaccination boosts for HCW.

Publisher

Nature Communications

Published On

Feb 08, 2021

Authors

Stéphane Marot, Isabelle Malet, Valentin Leduc, Karen Zafilaza, Delphine Sterlin, Delphine Planas, Adèle Gonthald, Aude Jary, Karim Dorgham, Timothée Bruel, Sonia Burrel, David Boutolleau, Olivier Schwartz, Guy Gorochov, Vincent Calvez, Anne-Geneviève Marcelin

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