Medicine and Health

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

L. Peng, Y. Hu, et al.

Discover the groundbreaking work by Lei Peng, Yingxia Hu, and their colleagues, as they unveil monoclonal antibodies that effectively neutralize SARS-CoV-2 variants. Their innovative approach, combining high-throughput single-cell sequencing and structural biology, offers new therapeutic alternatives against COVID-19 and its evolving strains.

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Playback language: English

Index

Abstract

This paper reports the development and characterization of monoclonal antibodies (mAbs) that potently neutralize SARS-CoV-2 variants. Using high-throughput single-cell sequencing of B cells from immunized animals, two potent neutralizing mAb clones were identified, and a bispecific antibody was generated. Cryo-EM structures were solved, revealing distinct epitopes and binding patterns. The mAbs showed potent efficacy in vivo, and a humanized antibody maintained strong potency against the original virus and the Delta variant. These findings expand the therapeutic options against SARS-CoV-2 and its variants.

Publisher

NATURE COMMUNICATIONS

Published On

Mar 28, 2022

Authors

Lei Peng, Yingxia Hu, Madeleine C. Mankowski, Ping Ren, Rita E. Chen, Jin Wei, Min Zhao, Tongqing Li, Therese Tripler, Lupeng Ye, Ryan D. Chow, Zhenhao Fang, Chunxiang Wu, Matthew B. Dong, Matthew Cook, Guilin Wang, Paul Clark, Bryce Nelson, Daryl Klein, Richard Sutton, Michael S. Diamond, Craig B. Wilen, Yong Xiong, Sidi Chen

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