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Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

Medicine and Health

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

Y. Guo, G. Zhang, et al.

Discover groundbreaking insights into broadly neutralizing antibodies against SARS-CoV-2 variants, including Omicron, as unveiled by the research team led by Yu Guo and collaborators. This study explores the potential of rationally designed antibody cocktails, showing exceptional effectiveness against various variants, making strides toward promising therapeutic solutions.

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Playback language: English
Abstract
This study aimed to discover broadly neutralizing antibodies against SARS-CoV-2 variants, especially Omicron. Using single-cell sequencing of B cells from Omicron breakthrough infection patients, they identified potent antibodies with low nanogram-per-milliliter NT50 values. Cryo-EM studies revealed structural mechanisms of broad neutralization. Rationally designed antibody cocktails demonstrated excellent neutralizing activity against all tested VOCs, including BQ.1.1 and XBB, offering a promising therapeutic candidate.
Publisher
Nature Communications
Published On
Jun 15, 2023
Authors
Yu Guo, Guangshun Zhang, Qi Yang, Xiaowei Xie, Yang Lu, Xuelian Cheng, Hui Wang, Jingxi Tang, Jielin Tang, Yuxin Gao, Hang Shang, Jun Dai, Yongka Shi, Jiazhi Zhou, Jun Zhou, Hangtian Guo, Haitao Yang, Jianwei Qi, Lijun Liu, Shihui Ma, Biao Zhang, Qianyu Huo, Yi Xie, Junpings Wu, Fang Dong, Song Zhang, Zhiyong Lou, Yan Gao, Zidan Song, Wenming Wang, Zixian Sun, Xiaoming Yang, Dongsheng Xiong, Fengjiang Liu, Xinwen Chen, Ping Zhu, Ximo Wang, Tao Cheng, Zine Rao
Tags
broadly neutralizing antibodies
SARS-CoV-2 variants
Omicron
antibody cocktails
cryogenic electron microscopy
therapeutic candidate
single-cell sequencing

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