Chemistry

Radical strain-release photocatalysis for the synthesis of azetidines

R. I. Rodríguez, V. Corti, et al.

Discover a groundbreaking method developed by Ricardo I. Rodríguez and team that synthesizes densely functionalized azetidines using a novel photocatalytic radical strategy! This innovative approach showcases remarkable efficiency and versatility, opening doors to new azetidine derivatives, including celecoxib and naproxen.

00:00

Playback language: English

Index

Abstract

This paper reports a novel photocatalytic radical strategy for synthesizing densely functionalized azetidines from azabicyclo[1.1.0]butanes. The method uses an organic photosensitizer to control energy transfer, leading to the formation of radical intermediates that react via a strain-release process. The reaction's efficiency and versatility are demonstrated through the synthesis of various azetidine derivatives, including those of celecoxib and naproxen.

Publisher

Nature Catalysis

Published On

Nov 01, 2024

Authors

Ricardo I. Rodríguez, Vasco Corti, Lorenzo Rizzo, Stefano Visentini, Marco Bortolus, Agnese Amati, Mirco Natali, Giorgio Pelosi, Paolo Costa, Luca Dell'Amico

Related Publications

Explore these studies to deepen your understanding of the subject.

Political Science

Rehumanizing the migrant: the translated past as a resource for refashioning the contemporary discourse of the (radical) left

M. Baker

Chemistry

Solvent-Pair Surfactants Enabled Assembly of Polyoxometalates and Amphiphilic Block Copolymers for the Synthesis of Functional Mesoporous Metal Oxides

W. Xu, Y. Ren, et al.

Chemistry

Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

M. Kondo, H. D. P. Wathsala, et al.

Chemistry

Electrochemical Insertion of Ammonia into Cyclic Alkenes for the Synthesis of Aromatic N-Heterocycles

S.i. and X.c.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny