This paper reports a novel electrochemical method for the direct insertion of ammonia into cyclic alkenes to synthesize diverse aromatic N-heterocycles. The method utilizes electrochemical hydrogen evolution, avoiding the need for external oxidants and achieving up to 99.2% theoretical atom economy. This approach offers advantages including tolerance of oxidation-labile functional groups and a broad substrate scope.
Publisher
Nature Communications
Published On
Oct 26, 2022
Authors
S.I., X.C.
Tags
electrochemical method
ammonia insertion
cyclic alkenes
aromatic N-heterocycles
hydrogen evolution
atom economy
functional group tolerance
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