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Psychedelics for major depression—From controlled research settings into broader clinical use
Medicine and HealthCell Reports Medicine

Psychedelics for major depression—From controlled research settings into broader clinical use

M. Avram and S. Borgwardt

Psychedelics have shown promising antidepressant effects in recent phase 2 randomized controlled trials, while phase 3 studies are now underway. This concise overview highlights clinical and mechanistic advances—from receptor pharmacology to subjective experience and context—and outlines priorities for future research. Research conducted by Mihai Avram and Stefan Borgwardt.... show more
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Abstract
Psychedelics have shown promising antidepressant effects in recent phase 2 randomized controlled trials, with phase 3 studies underway. While therapeutic outcomes are encouraging, the underlying mechanisms—from receptor-level pharmacology to subjective experience and context—remain only partially understood. We highlight clinical and mechanistic advances and outline priorities for future research.
Publisher
Cell Reports Medicine
Published On
Sep 16, 2025
Authors
Mihai Avram, Stefan Borgwardt
DOI
https://doi.org/10.1016/j.xcrm.2025.102361
Tags
psychedelicsantidepressant effectsphase 2 trialsphase 3 studiesmechanisms of actionreceptor pharmacologysubjective experience and context
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