The GEN-COVID Multicenter Study has collected biospecimens (whole blood, plasma, serum, leukocytes, DNA) from over 1000 SARS-CoV-2 positive individuals, linking them to detailed clinical data. Analysis revealed five clinical categories: (1) severe multisystemic failure; (2) cytokine storm; (3) moderate heart failure; (4) moderate multisystemic involvement; and (5) mild illness. The data, including whole-exome sequencing and SNP genotyping, are available through the Network for Italian Genomes. The study aims to identify multi-organ involvement, genetic parameters for infection susceptibility, and genetic mapping of COVID-19 severity.
Publisher
Springer Nature
Published On
Jan 17, 2021
Authors
Sergio Daga, Chiara Fallerini, Margherita Baldassarri, Francesca Fava, Fioriana Valentino, Gabriella Doddato, Elisa Benetti, Simone Furini, Annarita Giliberti, Rossella Tita, Sara Amitrano, Mirella Bruttini, Ilaria Meloni, Anna Maria Pinto, Francesco Raimondi, Alessandra Stella, Filippo Biscarini, Nicola Picchiotti, Marco Goni, Pietro Pinoli, Stefano Ceiri, Maurizio Sanarico, Francis P. Crawley, Giovanni Birollo, GEN-COVID Multicenter Study, Alessandra Renieri, Francesca Mari, Elisa Frullanti
Tags
SARS-CoV-2
COVID-19 severity
genetic susceptibility
clinical categories
biodata collection
multisystem involvement
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