Biology

Prefrontal Cortex-Specific Knockdown of Neurexin-1 in Rats Induces Anxiety-Like Behavior, Repetitive Behaviors, and Altered Social Interactions: A Proteomic Study

D. Wu, S. Zhang, et al.

This groundbreaking study by D Wu, S Zhang, Q Xu, L You, J Zhu, J Wang, and Y Li reveals the vital role of Neurexin-1 in the prefrontal cortex of rats, linking its knockdown to anxiety-like behaviors and significant changes in neuronal morphology. Discover how these findings could shed light on neurodevelopmental disorders!

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Abstract

This study investigated the effects of Neurexin-1 (NRXN1) knockdown in the prefrontal cortex (PFC) of rats on behavior and neuronal morphology. Researchers found that NRXN1 knockdown led to anxiety-like behavior, increased repetitive self-grooming, and altered social interaction patterns. Proteomic analysis revealed changes in the expression of 130 proteins, many associated with the extracellular matrix, cell membrane, and neuronal morphology. These findings suggest a crucial role for NRXN1 in regulating neuronal development and behavior, potentially contributing to the pathophysiology of neurodevelopmental disorders.

Publisher

Journal of Neurodevelopmental Disorders

Published On

Mar 01, 2023

Authors

D Wu, S Zhang, Q Xu, L You, J Zhu, J Wang, Y Li

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