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Abstract
This study investigated the effects of Neurexin-1 (NRXN1) knockdown in the prefrontal cortex (PFC) of rats on behavior and neuronal morphology. Researchers found that NRXN1 knockdown led to anxiety-like behavior, increased repetitive self-grooming, and altered social interaction patterns. Proteomic analysis revealed changes in the expression of 130 proteins, many associated with the extracellular matrix, cell membrane, and neuronal morphology. These findings suggest a crucial role for NRXN1 in regulating neuronal development and behavior, potentially contributing to the pathophysiology of neurodevelopmental disorders.
Publisher
Journal of Neurodevelopmental Disorders
Published On
Mar 01, 2023
Authors
D Wu, S Zhang, Q Xu, L You, J Zhu, J Wang, Y Li
Tags
Neurexin-1
knockdown
prefrontal cortex
anxiety-like behavior
neuronal morphology
proteomic analysis
neurodevelopmental disorders

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