Medicine and Health

Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes

Y. Yang, C. Zhang, et al.

This study by Yang Yang, Cheng Zhang, and Hui Gao highlights a concerning link between exposure to certain chemicals and diabetes risk, exacerbated by low intake of dietary antioxidants. The research underscores potential underlying mechanisms affecting glucose metabolism, prompting a closer look at environmental risks in our quest for better health.

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Playback language: English

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Abstract

This study investigated the association between co-exposure to phthalate esters (PAEs) and organophosphate esters (OPEs) and diabetes, the modifying effect of dietary antioxidants, and potential mechanisms. Using data from NHANES 2011-2018, a higher environmental risk score (ERS) for PAEs and OPEs was significantly associated with increased diabetes risk. This association interacted with dietary antioxidant intake, with a stronger association observed in individuals with low antioxidant intake. Quantile g-computation confirmed the positive association between combined exposure and diabetes, which was attenuated by the addition of dietary antioxidants. Adverse outcome pathway (AOP) analysis implicated TCPP and TCEP as key chemicals affecting glucose metabolism and insulin signaling, leading to diabetes.

Publisher

Nutrition and Diabetes

Published On

Sep 03, 2024

Authors

Yang Yang, Cheng Zhang, Hui Gao

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