Medicine and Health

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

D. Sun, Z. Sang, et al.

This study explores the transformative potential of nanobodies in neutralizing SARS-CoV-2 variants, revealing their resistance to variants of concern and the discovery of unique neutralizing epitopes. Conducted by a talented team of researchers from the University of Pittsburgh and beyond, the findings highlight nanobodies' advantages over traditional antibodies, paving the way for innovative pan-coronavirus vaccines and therapeutics.

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Abstract

This study investigates the effectiveness of nanobodies (Nbs) in neutralizing circulating SARS-CoV-2 variants. Researchers found that RBD Nbs are highly resistant to variants of concern (VOCs). High-resolution cryo-electron microscopy revealed three classes of potent neutralizing epitopes: Class I targets ACE2-binding sites; Class II binds conserved epitopes; and Class III recognizes unique, antibody-inaccessible epitopes. Comparisons with neutralizing antibodies highlighted the advantages of Nbs in achieving high-affinity and broad neutralization. The study suggests potential applications in designing pan-coronavirus vaccines and therapeutics.

Publisher

NATURE COMMUNICATIONS

Published On

Aug 03, 2021

Authors

Dapeng Sun, Zhe Sang, Yong Joon Kim, Yufei Xiang, Tomer Cohen, Anna K. Belford, Alexis Huet, James F. Conway, Ji Sun, Derek J. Taylor, Dina Schneidman-Duhovny, Cheng Zhang, Wei Huang, Yi Shi

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