Medicine and Health

Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes

M. Hivert, F. White, et al.

Explore the fascinating role of placental insulin-like growth factor binding protein 1 in pregnancy glycemic physiology! This insightful research reveals that higher levels of IGFBP1 are linked to greater insulin sensitivity, while low levels in early pregnancy could indicate the risk of gestational diabetes mellitus. This study comes from the expert collaboration of Marie-France Hivert and colleagues.

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Abstract

Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). This study identified a positive association between placental insulin-like growth factor binding protein 1 gene (*IGFBP1*) expression and insulin sensitivity. Higher circulating IGFBP1 levels were associated with greater insulin sensitivity, while low levels in early pregnancy predicted subsequent GDM diagnosis. These results implicate IGFBP1 in pregnancy glycemic physiology and suggest a role for placental IGFBP1 deficiency in GDM pathogenesis.

Publisher

Nature Medicine

Published On

Jun 01, 2024

Authors

Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe

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