Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). This study identified a positive association between placental insulin-like growth factor binding protein 1 gene (*IGFBP1*) expression and insulin sensitivity. Higher circulating IGFBP1 levels were associated with greater insulin sensitivity, while low levels in early pregnancy predicted subsequent GDM diagnosis. These results implicate IGFBP1 in pregnancy glycemic physiology and suggest a role for placental IGFBP1 deficiency in GDM pathogenesis.
Publisher
Nature Medicine
Published On
Jun 01, 2024
Authors
Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
Tags
insulin resistance
gestational diabetes
IGFBP1
pregnancy
insulin sensitivity
glycemic physiology
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