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Physical exercise restores adult neurogenesis deficits induced by simulated microgravity

Medicine and Health

Physical exercise restores adult neurogenesis deficits induced by simulated microgravity

A. Gros, F. M. Furlan, et al.

This groundbreaking study by Alexandra Gros and colleagues explores how simulated microgravity affects neurogenesis in rats, revealing that physical exercise can counteract its impacts on brain cell proliferation and survival. The results suggest new insights into space research and its implications for human health.

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Playback language: English
Abstract
This study investigated the effects of simulated microgravity (SMG) on adult neurogenesis in rats and the potential of physical exercise as a countermeasure. Seven days of SMG, but not shorter durations, reduced newborn cell proliferation in the dentate gyrus (DG) and short-term survival in the subventricular zone (SVZ)/olfactory bulb (OB) and DG. Physical exercise reversed the decrease in newborn cell survival in the SVZ and DG. Transcriptomic analysis revealed transient changes in gene expression involved in neurogenesis.
Publisher
npj Microgravity
Published On
Jun 21, 2024
Authors
Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel
Tags
simulated microgravity
adult neurogenesis
physical exercise
cell proliferation
gene expression

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