Medicine and Health

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Y. Hagihara, A. Sakamoto, et al.

Discover the groundbreaking potential of the photoactivatable oncolytic adenovirus (paOAd), engineered by Yasuko Hagihara and team, to revolutionize cancer therapy. This innovative approach harnesses blue light to activate the virus, leading to remarkable tumor growth inhibition without harmful side effects when not triggered. A leap forward in targeting even the most resilient cancer stem cells.

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Abstract

This research introduces a photoactivatable oncolytic adenovirus (paOAd) designed to enhance the safety and efficacy of oncolytic adenovirus-based cancer therapy. paOAd's replication is triggered by blue light irradiation, leading to efficient cancer cell lysis in vitro and significant tumor growth inhibition in both subcutaneous and liver cancer mouse models. Importantly, no off-tumor toxicity was observed in the absence of light irradiation. The study also demonstrated paOAd's effectiveness against cancer stem cells.

Publisher

Cell Death and Disease

Published On

Jan 01, 2020

Authors

Yasuko Hagihara, Ayaka Sakamoto, Takashi Tokuda, Tomoki Yamashita, Sena Ikemoto, Ayaka Kimura, Makito Haruta, Kiyotaka Sasagawa, Jun Ohta, Kazuo Takayama, Hiroyuki Mizuguchi

DOI

https://doi.org/10.1038/s41419-020-02782-6

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